Trojan Horse Gold Particles Could Finally Treat Brain Tumours

By Pranav Dixit on at

Glioblastoma multiforme is a cancer that's as deadly as it sounds. It's the most common and aggressive brain tumour in adults that's especially difficult to remove surgically because the tumour cells invade the surrounding, healthy brain tissue. Victims typically die within a few months of diagnosis; just six in every 100 patients make it past the five-year mark. The good news is that we now have a technique to treat it.

The "trojan horse" treatment involves using tiny nano particles containing both gold and cisplatin, a conventional chemotherapy drug, according to Here's how the process works:

These [particles] were released into tumour cells that had been taken from glioblastoma patients and grown in the lab. Once inside, these "nanospheres" were exposed to radiotherapy. This caused the gold to release electrons which damaged the cancer cell's DNA and its overall structure, thereby enhancing the impact of the chemotherapy drug.

Apparently, the process was super effective and 20 days later, all evidence pointed to cancer cells being completely destroyed, leaving healthy tissue unharmed.

The study was led by Mark Welland, Professor of Nanotechnology and a Fellow of St John's College, University of Cambridge, and Dr Colin Watts, a clinician scientist and honorary consultant neurosurgeon at the Department of Clinical Neurosciences. Head over to for more fascinating insights. [ Top Image: M. Welland via]