Much like climate change, the growing emergence of antibiotic-resistant bacterial superbugs is a ticking time bomb that threatens our very way of life. It’s also a very expensive problem to tackle, and Big Pharma has struggled to find any promising solutions. On Wednesday, yet another major pharmaceutical—the Swiss-based Novartis—announced it is dropping out of the antibiotics game.
Novartis, Endpoints News first reported, will shut down its antibacterial and antiviral research programmes and lay off 140 employees at its Emeryville, California, US location. The cuts are also expected to affect other areas of the company, such as its pharmacology and protein sciences branches. Most of the laid-off employees will receive two months of severance, while a few will stay on to help shutter the programmes.
“While the science for these programmes is compelling, we have decided to prioritise our resources in other areas where we believe we are better positioned to develop innovative medicines that will have a positive impact for patients,” Novartis said in a statement, Endpoints News reported. The company will also attempt to sell the licenses to any ongoing projects, such as experimental antimicrobials in the early phases of research, to other companies.
Novartis’ exit is only the latest sign of Big Pharma’s hesitance to pursue antibiotic research; AstraZeneca and Eli Lilly have also shuttered their antibiotics research programmes in recent years. While new antibiotics are still regularly discovered, their development and potential has slowed to a crawl over the decades.
That’s partly because newer drugs are often only a slight improvement over existing drugs in the same class. But antibiotics are also not that profitable, at least when compared to the latest heart medication or erectile dysfunction drug. Even when a new antibiotic does hit the market, it’s unlikely to recoup a company’s costs of shepherding it through the approval process; thanks to the legitimate fear of speeding along antibiotic resistance, newer drugs are typically used as a last resort for resistant infections, limiting their profit margins.
Governments and outside organisations have tried to convince pharma companies to keep their antibiotic research programs going through generous subsidies and funding investments in recent years, while smaller boutique research firms have also stepped in. But there’s no clear indication that these efforts are really paying off.
In the meantime, bacteria are simply winning the arms race, outpacing the development of new drugs and programmes designed to combat resistance. This year alone, there were three cases of gonorrhoea found to be completely untreatable through standard medication. Similar cases involving different bugs will inevitably come.
Already, superbugs are responsible for 700,000 deaths a year worldwide. But by 2050, barring any last-minute miracle, they could kill an estimated 10 million people annually—a death toll higher than all cancers combined. [Endpoints News]